Vice President, Head of Chemistry

Location: Cambridge, MA

Job Code:

H3 Biomedicine seeks an experienced, highly motivated medicinal chemist to lead our Chemistry team located in Cambridge, MA. The successful candidate will have over 15 years of medicinal chemistry experience with a strong background in synthetic organic chemistry and a track record of delivering clinical candidates. This individual will be driven to succeed within a hypothesis-driven, team-oriented, and multi-disciplinary biotech environment. The individual will be expected to contribute to all stages of drug discovery programs, advancing both small and large molecules from hit identification to IND.

Principal Duties and Responsibilities

  • Supervise and direct the efforts of all chemistry staff focused on developing a portfolio of precision medicine based small molecule and large molecule therapeutics in oncology.
  • Provide leadership, strategic oversight, resource management, and organizational framework to ensure timely delivery of pipeline projects.
  • Prioritize all chemistry activities, managing both internal and external chemistry resources to achieve company goals while ensuring adherence to timelines and budgets.
  • Ensure that the management of contract research organization (CRO) partners and the alignment of external resources consistent with company priorities and objectives to build a strong portfolio of drug candidates.
  • Build and maintain productive relationships with partners in biology, DMPK, toxicology, CMC, and early development.
  • Plan and lead IP and scientific publication strategy.
  • Identify, support, manage and develop talents; acting as a resource and mentor to team members—providing guidance, instruction, feedback and coaching.
  • Build a dynamic scientific and professional culture focused on productivity and innovation that reflects H3 Biomedicine’s values.
  • Manage communication and build strong collaborative relationships with key stakeholders both internally and externally.
  • Professionally represent the organization externally in collaborations, partnership discussions, and conferences, board of directors, and scientific advisory board.
  • Maintain high standards of laboratory safety, complying with all H3 Biomedicine’s safety requirements.


  • Ph.D. in Organic Chemistry or related field with 15+ years of industry experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist.
  • Demonstrated experience delivering multiple compounds from hit to IND, preferably in the field of oncology experience in the field of antibody drug conjugates is an added advantage.
  • Demonstrated leadership in medicinal chemistry and drug discovery as evidenced by a strong record of drug delivery, scientific accomplishment and cross-functional collaboration.
  • Experience building and managing chemistry teams in a matrix organization and oversite of Analytical Chemistry.
  • Outstanding synthetic chemistry background and a demonstrated track record of aptitude and problem solving in medicinal chemistry.
  • Extensive working knowledge of modern medicinal chemistry and drug discovery techniques (FBDD, SBDD, multi-attribute analysis, flexible resourcing models, alternative drug delivery systems, etc.).
  • Proven ability to manage timelines and resources to drive projects toward key decision criteria.
  • Extensive experience interfacing with, and providing scientific guidance to CRO partners and proven ability to work efficiently in a hybrid model.
  • Keen attention to detail and a strong sense of urgency is required, as is the desire and ability to work in a multi-disciplinary and team-focused environment.
  • Excellent written and oral communication skills.

About H3 Biomedicine Inc.

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole mission is to become a prolific source of new drugs that treat more human cancers with greater success. H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs.

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