System Administrator Role

Location: Cambridge, MA

Job Code:

Cambridge, MA-based H3 Biomedicine (H3B) is a leading company in cancer genomics driven drug discovery, delivering on the promise of precision medicine. The company was launched in 2011 with an unprecedented $200 million in initial funding from Eisai, plus a continued ongoing commitment to fund H3B’s robust discovery pipeline and clinical programs. Now with three clinical stage anti-cancer molecules in active development, H3B is able to uniquely leverage distinct insights from cancer genomics and real-life patient data to advance its projects to clinical proof of concept and beyond. H3B embraces a novel business model in which it collaborates with Eisai, a leading global pharmaceutical company, to create a prolific drug discovery engine and partnership platform.   H3B has built a strong data science team with varied scientific background, skillset and responsibilities, spanning data analytics, cancer genomics, bioinformatics, scientific data management and integration to high performance computing. The team has been fully integrated in our research and development organization as a core strength.

At H3 Biomedicine, the IT department strives to provide secure reliable computing system infrastructure, tools, and advice in order to enable H3's data driven philosophy for research and development of new therapeutics. We’re seeking an experienced systems administrator who is eager to use and grow his or her technological skills. In this role, reporting directly to the Director of Information Technology, the successful individual will protect our critical information, systems, and assets; as well as build solutions, implement new software and hardware, provide training, and assist in the development of an overall IT strategy. From early on, you’ll help empower our breakthrough innovations, be given challenging assignments, lead initiatives, and take ownership and responsibility. Our ideal candidate will be passionate about applying their current skills and develop new skills in order to further H3’s mission.

Principal Duties and Responsibilities

  • Develop and implement project plans
  • Proactively manage, maintain and monitor
    • Public cloud infrastructure (AWS)
    • On premises server infrastructure (Windows, Linux, physical and virtual)
    • On premises network infrastructure (WiFi, routers, switches, firewalls)
    • On premises storage infrastructure (Isilon, Avere, CIFS/NFS file sharing)
    • Software-as-a-Service (Box, G Suite, Lucidchart, Jive, etc)
    • Endpoints (Lab instrument computer management, mobile devices, Windows/Mac/Linux)
  • Develop and implement IT security best practices
    • Endpoint security
    • Network security
    • Operating system and application security
    • public key infrastructure
    • Encryption technologies and techniques
  • Maintain inventory and asset tracking
    • Hardware and software support contracts and warranties
  • Assist with hardware, firewall, telecom and software vendor evaluation, recommendation and negotiations
  • Interact with staff across all departments and levels to assess needs and deliver solutions
  • Mentor / cross train team members on existing and new technologies
  • Interact with the help desk and other teams to assist in troubleshooting, identify root cause, and provide technical support when needed


  • Bachelor’s degree in computer science (or related area) preferred &/or at least 5 - 7 years' related experience as noted herein
  • Advanced knowledge of Linux server operating systems and expertise with Windows server operating systems
  • Advanced understanding of networking concepts and technologies (LAN/WAN, DNS, DHCP, etc)
  • A solid understanding of web technologies (domains, IIS, Apache, etc)
  • Hands on experience with automation and configuration practices and tools such as Ansible
  • Managing server virtualization technologies like VMWare Server and Nutanix systems
  • Working knowledge of modern database technologies
  • Experience managing Microsoft Active Directory (Group Policy design and configuration, user and group administration, LDAP)
  • Understanding of mobile technologies (IOS, Android)
  • Understanding of IT security best practices and implementation (IAM, PKI, encryption)
  • Ability to manage external services providers
  • Strong communication and documentation skills
  • Flexible and able to adapt to a rapidly changing environment
  • Must be organized and have the ability to manage projects of varying length
  • Positive, self-motivated individual who can complete tasks independently
  • Must be a team player

About H3 Biomedicine Inc.

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole mission is to become a prolific source of new drugs that treat more human cancers with greater success. H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs.

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