Senior Research Associate/Investigator I, Medicinal Chemistry

Location: Cambridge, MA

Job Code:

H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics. We are looking for an experienced and highly motivated medicinal chemist to join our research team in Cambridge, MA.  This hire will have a strong background in synthetic organic chemistry and cancer biology, and is driven to succeed inside our hypothesis-driven, team-oriented and multi-disciplinary biotech environment. The individual will be expected to contribute to all stages of drug discovery programs, advancing small molecules from hit identification to development candidate selection, and will strengthen a team that consists of both internal employees and external (CRO) partners.

The ideal candidate is an experienced bench chemist with expertise in drug discovery/medicinal chemistry, or a highly motivated entry level Ph.D. with industrial experience in med chem/synthetic organic chemistry. He/She is independent, motivated and experimentally skilled with a strong track record of lab results and interest in designing and synthesizing compounds.  Primarily lab-based, he/she independently contributes to lead generation and the creation of a unique compound collection through traditional and parallel synthesis to optimize hits and lead series toward a drug candidate.  Possesses strong communication skills,  an eagerness to learn and ability to work well in teams.

Principal Duties and Responsibilities

  • Design new &/or Independently extend existing synthetic routes for compounds as required.
  • Design &/or execute experiments using basic principles to solve problems & improve chemical processes.
  • Independently execute syntheses of target compounds.
  • Characterize synthesized compounds as to composition and purity.
  • Identify and introduce new experimental techniques to address research problems.
  • Utilize literature searches to solve specific and general research problems.
  • Devise and communicate working models to explain research results in program context.
  • Contribute to the preparation and submission of patents, scientific publications &/or regulatory documents.
  • Be able to understand failed reactions and propose modifications.
  • Understand and apply knowledge of the chemical and biological issues affecting the project.
  • Learn, acquire and apply new experimental techniques; contribute new ideas to the project team.
  • Provide conceptual contributions toward project advancement.
  • Communicate and relate research results within project context.
  • Utilize literature searches to solve specific research problems.
  • Become familiar with research activities within project context.
  • Work together with other members of a project group to accomplish team objectives.
  • Communicate research results in an appropriate, accurate and timely manner.
  • Present research results for company reviews.
  • Participate in research group, project meetings and planning/recruitment of research staff
  • Maintain an accurate and current record of experimental results in an electronic laboratory notebook.
  • Anticipate needs and plan for the purchase, use, and maintenance of laboratory equipment.
  • Utilize training and resources (external and internal) to stay current in chemistry.
  • Maintain high standards of laboratory safety, comply with H3 safety manual and complete required training.
  • Maintain laboratory equipment, and train others in its use.


  • Ideally a Master’s degree in Chemistry with 10+ years of industrial experience in medicinal chemistry; or
  • Ph.D. in organic chemistry with 0-3 years industrial experience in medicinal chemistry/synthetic organic chemistry
  • Strong technical or experimental expertise and demonstrated ability to:
    • Independently identify and solve significant problems
    • Independently plan work over extended periods of time to optimize laboratory productivity
    • Independently design efficient and well-controlled experiments
    • Communicate effectively across disciplines
    • Evaluate and prioritize research efforts within broader team objectives
    • Work with minimal supervision and Simultaneously balance multiple tasks
    • Show initiative to expand scope and depth of technical competence
    • Act as technical resource in a defined area
    • Independently plan work to support team and project objectives
    • Work together with other members of a project team to accomplish team objectives
    • Generalize experimental design and clearly communicate ideas and research results

About H3 Biomedicine Inc.

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole mission is to become a prolific source of new drugs that treat more human cancers with greater success. H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs.

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