Lab Head – Target & Drug Discovery Cancer Biology

Location: Cambridge, MA

Job Code:

We are seeking an energetic and self-motivated scientific leader, who will lead the development and implementation of new science and strategies for H3’s lead targets. This PhD level scientist will join a team of scientists working towards discovery of unique anti-cancer compounds for the treatment of targeted patient populations. The candidate will be a highly creative cancer biologist with a strong desire to succeed at the highest level. This individual will lead target and drug discovery projects in a team environment and direct the activities of a research associate under their supervision.

Principal Duties and Responsibilities

Lead drug discovery efforts to selection of lead candidate and transition into clinical development Independently design, execute and interpret in vitro/in vivo pharmacology experiments to optimize compound selection and explore therapeutic potential of drug targets Identify pharmacodynamic assays for utility in pre-clinical and clinical setting; define PK/PD/efficacy relationships and test patient selection strategies Participate in target discovery efforts and evaluate new targets by applying state of the art molecular biology and genetic methodology Work collaboratively across multiple disciplines, including Bioinformatics and Chemistry to drive projects Interpret, present and report research findings at internal meeting an external scientific conferences Manage and direct the activities of a research associate


  • Ph,D or equivalent in cell/molecular biology, pharmacology or genetics
  • Strong post-doc experience in Cancer Biology, 1-2 years industry experience desired
  • Experience with in vitro and in vivo pharmacology methodologies
  • Excellent interpersonal skills with a record of energizing teams
  • Flexibility to accommodate to rapidly changing priorities and deadlines
  • Ability to work in a team-based environment
  • Excellent oral and written communication skills

About H3 Biomedicine Inc.

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole mission is to become a prolific source of new drugs that treat more human cancers with greater success. H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs.

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