Investigator I, Medicinal Chemistry

Location: Cambridge, MA

Job Code:

H3 Biomedicine, seeks experienced and highly motivated synthetic organic chemist to join its research team located in Cambridge, MA. The ideal candidate has a strong background in synthetic organic chemistry and is driven to succeed within a hypothesis-driven and team-oriented biotech environment. The individual will be expected to contribute to all stages of drug discovery programs, advancing small molecules from hit identification to development candidate selection.

Principal Duties and Responsibilities

Design, plan and execute in a laboratory setting, the synthesis of high quality small molecules for biological screening Identify, develop and optimize new chemical methods/techniques to address specific analog synthesis challenges Devise and implement medicinal chemistry strategies addressing critical project issues. Responsible for communicating project updates to management team, internal colleagues and external collaborators Coordination of project activities with other disciplines including structural biology, target compound profiling, biology and pharmacology Assist in the preparation of patent documents and peer reviewed scientific publications Maintain high standards of laboratory safety whilst complying with all H3 safety requirements


Ph.D. in Organic Chemistry, or an MS in Organic Chemistry with at least 6 years’ experience working in industry as a medicinal chemist. Deep understanding of synthetic chemistry, as evidenced by a record of achievement (publications, patents, etc.). Strong knowledge of techniques related to synthesis, purification and structural characterization of organic compounds Exposure to the fundamental concepts and tools of structure based drug design as applied to drug discovery programs Experience with natural product synthesis on scale Involvement with successful drug discovery projects, particularly those focused on kinases, nuclear hormone receptors or targeting reactive cysteine residues.

About H3 Biomedicine Inc.

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole mission is to become a prolific source of new drugs that treat more human cancers with greater success. H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs.

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