H3 Biomedicine

Sensitivity to Splicing Modulation of BCL2 Family Genes Defines Cancer Therapeutic Strategies for Splicing Modulators

Dysregulation of RNA splicing by spliceosome mutations or in cancer genes is increasingly recognized as a hallmark of cancer. Small… Read More

Splicing Modulation as Novel Therapeutic Strategy Against Diffuse Malignant Peritoneal Mesothelioma

Introduction: Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival… Read More

Nonclinical Pharmacokinetics and in Vitro Metabolism of H3B-6545, a Novel Selective ERα Covalent Antagonist (SERCA)

Purpose: H3B-6545, a novel selective estrogen receptor (ER)α covalent antagonist (SERCA) which inactivates both wild-type and mutant ERα, is in… Read More

Effect of a High-Fat Meal on the Relative Bioavailability of H3B-6527, a Novel FGFR4 Inhibitor, in Healthy Volunteers

Purpose: This Phase I study estimated the effect of a high-fat meal on the pharmacokinetics (PK) of H3B-6527, a covalent… Read More