Genes & Development | February 7, 2018 The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action Somatic mutations in spliceosome proteins lead to dysregulated RNA splicing and are observed in a variety of cancers. These genetic… Read More
Nature Medicine | February 19, 2018 H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers Genomic analyses of cancer have identified recurrent point mutations in the RNA splicing factor–encoding genes SF3B1, U2AF1, and SRSF2 that… Read More
March 19, 2018 H3 Biomedicine to Present at the BioCentury Annual Future Leaders in the Biotech Industry Conference Read More
Cancer Cell | March 12, 2018 Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS To identify novel targets for acute myeloid leukemia (AML) therapy, we performed genome-wide CRISPR-Cas9 screening using AML cell lines, followed… Read More